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深度学习心声信号,有效预测阻塞性冠状动脉疾病
Aikeliyaer Ainiwaer1, Wen Qing Hou2, Quan Qi3
1Department of Cardiology, First Afliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang, 830000, China.
使用心脏声音的新型深度学习模型可以有效地选阻塞性冠状动脉疾病 (CAD),减少不必要的侵入性手术. 这种非侵入性方法在冠状动脉血管学 (CAG) 之前识别显著阻塞时具有高准确性.
科学领域:
- 心脏病学 心脏病学
- 医学诊断 医学诊断 医学诊断
- 医疗保健中的人工智能
背景情况:
- 目前用于检测阻塞性冠状动脉疾病 (CAD) 的方法有局限性,导致不必要的冠状动脉血管学 (CAG) 转诊.
- 对阻塞性CAD进行准确和有效的查对于优化患者管理和资源配置至关重要.
研究的目的:
- 开发一个全面的数据库心脏声音在患有CAD的患者.
- 创建和验证深度学习算法,以使用心脏声音信号有效检测阻塞性CAD.
- 建立一个非侵入性查工具,以减少不必要的CAG转诊.
主要方法:
- 使用先进的过和深度学习模型 (VGG-16,1D CNN,ResNet18) 来分析320名疑似患有CAD的受试者的心脏声信号.
- 阻塞性CAD定义为至少有一种狭窄 ≥50%.
- 在另外80个科目中进行前性验证.
主要成果:
- 在测试组中,VGG-16型号获得了最高的性能,ROC曲线下的面积 (AUC) 为0.834.
- 组合模型 (VGG与DF或PTP分数) 显示出优异的性能,AUC分别为0.915和0.908.
- 在检测冠状动脉封闭和多血管疾病方面,VGG-16显示出高灵敏度和特异性 (>0.85).
结论:
- 使用心脏声音的深度学习模型提供了一种非侵入性和有效的查方法,用于阻塞性CAD.
- 预计这种方法将大大减少对CAG等侵入性诊断程序的不合理转诊人数.
- 心脏声音分析为早期和准确检测冠状动脉疾病提供了一个有希望的途径.
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