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脊髓淋巴结转移对脊髓腺癌远程转移的影响
Fan Meng1, Junhui Yuan1, Xu Zhang2
1Department of Radiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.
Frontiers in oncology
|January 3, 2024
概括
阳性乳头淋巴结 (LNs) 的数量显著影响乳头癌的远程转移. 然而,这些LNs的外节延伸 (ENE) 并没有影响远程无转移存活率 (DMFS).
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 病理学 病理学 病理学
背景情况:
- 口腔癌是一种复杂的恶性瘤,预后各异.
- 淋巴结转移是状腺癌进展的关键因素.
- 了解远程转移的预测因素对于治疗规划至关重要.
研究的目的:
- 调查阳性侧侧淋巴结 (LNs) 数量对远程转移的预后影响.
- 评价阳性侧鼻线性LNs在远程转移中的突节外延伸 (ENE) 的作用.
- 确定状腺癌患者的状腺LN特征与远程无转移生存率 (DMFS) 之间的关联.
主要方法:
- 对经过手术治疗的癌患者的回顾性分析.
- 利用考克斯回归模型来评估DMFS的危险比率 (HRs).
- 评估了阳性状线索和ENE数量对生存结果的影响.
主要成果:
- 阳性状线索细胞数量的增加与DMFS的减少有显著的关联.
- 两个阳性LN的患者的HR为2.11;三个或更多的患者的HR为3.31.
- 阳性状线索外节延伸 (ENE) 对DMFS没有显著影响 (p=0.462).
结论:
- 状淋巴结转移是状淋巴结癌中减少DMFS的重要预测因子.
- 阳性状LNs的数量是远程转移的更强的预测指标,而不是ENE.
- 这些发现强调了淋巴结负担在评估状腺癌预后方面的重要性.
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