精致的饮食消费增加神经炎症信号通过胆酸代谢不良通过胆酸代谢不良
Emily Connell1, Britt Blokker1, Lee Kellingray2
1Norwich Medical School, University of East Anglia, Norwich, UK.
Nutritional neuroscience
|January 3, 2024
概括
一种精致的低脂肪饮食会改变肠道细菌和胆酸,影响微生物群-肠道-大脑轴,并可能导致神经炎症. 这项研究强调了加工食品如何通过肠-大脑通信影响认知健康.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
- 饮食科学 饮食科学
背景情况:
- 现代饮食中越来越多的超加工食品,往往缺乏必要的生物活性化合物.
- 肠道微生物群通过微生物群-肠道-大脑轴与大脑进行通信,影响认知功能.
- 饮食变化会破坏肠道微生物平衡,影响宿主健康.
研究的目的:
- 研究精制低脂肪饮食 (rLFD) 对微生物群-肠-大脑轴的影响.
- 专门研究胆汁酸代谢在这种饮食环境中的作用.
- 评估饮食,肠道微生物群和神经炎症之间的关系.
主要方法:
- 给小鼠吃RLFD或标准食饮食八周.
- 使用了多种omics方法,包括微生物组测序和代谢学.
- 分析的重点是肠道微生物多样性,短链脂肪酸,胆酸特征和神经炎症基因表达.
主要成果:
- rLFD诱导了显著的肠道微生物失调症,其特点是减少的α和改变的β多样性.
- 精制的饮食导致短链脂肪酸的减少和结肠和大脑中的胆酸度的失调.
- 改变的胆酸概况与神经炎症基因表达的变化相关,包括NF-κB1.1.
结论:
- 一种精致的低脂肪饮食会对肠道微生物和胆酸代谢产生负面影响.
- 这些变化破坏了微生物群-肠-大脑轴,可能导致有害的神经元过程和神经炎症.
- 针对肠道健康的饮食干预可能对维持认知功能至关重要.
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