血LRG1与亚洲2型糖尿病患者较低认知功能的相关性
Serena Low1,2,3, Angela Moh1, Bhuvaneswari Pandian1
1Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828.
The Journal of clinical endocrinology and metabolism
|January 3, 2024
概括
高水平的氨酸富含α-2-糖蛋白1 (LRG1) 与2型糖尿病患者的认知功能较差有关. 这种关联部分是由动脉硬性解释的,这表明潜在的治疗点.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 心血管医学 心血管医学
背景情况:
- 富含白的α-2-糖蛋白1 (LRG1) 与糖尿病并发症有关.
- 目前尚不清楚LRG1在2型糖尿病 (T2DM) 的认知功能中的作用.
研究的目的:
- 调查LRG1与T2DM患者认知功能之间的纵向关联.
- 使用孟德尔随机化 (MR) 确定因果关系.
- 评估动脉硬的调解作用.
主要方法:
- 在5.3年内对1039名T2DM患者进行了长度研究.
- 血LRG1通过ELISA测量;用RBANS评估认知功能.
- 使用脉冲波速度 (PWV) 进行单样MR和调解分析.
主要成果:
- 基线LRG1升高与基线和随访时的认知功能相反相关.
- 基因预测较高的LRG1与较低的后续认知得分相关.
- 较高的PWV介导了LRG1认知功能关联的27.7%.
结论:
- 基线血LRG1与T2DM患者的认知功能下降有关.
- 动脉硬度 (PWV) 部分调解了这一关联.
- MR 分析支持遗传影响LRG1与认知衰退之间的联系.
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