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Parnia Saeedi¹, Gilda Eslami², Masoud Tohidfar³

¹Department of Medical Parasitology and Mycology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

|January 3, 2024

概括

由Giardia duodenalis引起的Giardiasis改变了人类的基因表达. 关键的亡和抗亡基因,如AKT1,CDKN2A和KRAS,在有病史的人群中表达增加.

科学领域:

分子生物学分子生物学
遗传学是一个遗传学.
寄生虫学的寄生虫学

背景情况:

由Giardia duodenalis引起的巨病,呈现出类似于流病的症状,并对儿童构成风险.
寄生虫在癌症组织中的存在表明它可能在细胞过程中发挥作用.
了解Giardia对宿主基因表达的影响对于管理感染后并发症至关重要.

研究的目的:

为了分析与亡和抗亡相关的基因表达特征,在有亡病史的个体中.
为了确定受Giardia duodenalis感染影响的特定人类基因.
为了研究基底的分子机制潜在的长期影响的巨病.

主要方法:

基因表达数据集的元分析 (GSE113666,GSE113667,GSE113679) 来自基因表达集.
使用Cytoscape和STRING数据库进行蛋白质与蛋白质相互作用网络分析.
基因和基因组的京都百科全书和基因本体学分析用于途径识别.
在8个个体中使用实时聚合酶链反应验证基因表达.

主要成果:

在健康和巨症组之间,SAA1,REG3G和REG3A基因的表达没有显著差异.
与对照人群相比,在有病史的人群中观察到AKT1,CDKN2A和KRAS基因的表达增加.
细胞灭绝和抗细胞灭绝信号通路中的基因表达模式在具有病史的个体中发生了改变.

结论:

双胞胎感染似乎影响宿主基因表达,可能导致感染后症状.
这项研究强调了由于巨病的结果而改变的亡和抗亡信号.
需要进一步的研究来阐明Giardia感染的长期分子影响.

关键词:

癌症癌症癌症癌症候选基因是一个候选基因.不同基因表达的差异性十二指肠 (Giardia duodenalis) 是一个严重的疾病.

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