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当地识别分析,参数子集选择和验证,用于最小大脑PBPK模型

Kamala Dadashova1, Ralph C Smith1, Mansoor A Haider2

  • 1Department of Mathematics, North Carolina State University, Box 8205, Raleigh, NC, 27695, USA.

Bulletin of mathematical biology
|January 3, 2024
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模有助于了解药物向大脑的输送. 一个新的算法识别了大脑PBPK模型中的关键参数,提高了抗体治疗的准确性.

关键词:
能源统计 能源统计可以识别的可识别性当地敏感性分析.在 PBPK 建模中使用 PBPK 模型.参数子集选择参数子集的选择.

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