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视神经头部血液流量的变化 在水平眼膜伸缩过程中
Manami Kawai1, Toshiaki Goseki1,2, Kazunori Hirasawa1
1Department of Ophthalmology, Kitasato University School of Medicine, Kanagawa, Japan.
Investigative ophthalmology & visual science
|January 3, 2024
概括
视神经头部 (ONH) 血流在眼睛运动时减少,无论是健康的还是青光眼患者. 然而,在这些运动期间血流的相对变化在所有组中都是相似的,这表明在正常眼睛和青光眼之间对眼球导管的ONH血管反应没有显著差异.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 玻璃眼是导致不可逆转失明的主要原因.
- 视神经头部 (ONH) 血流对于视网膜质细胞的存活至关重要.
- 了解眼部运动期间的ONH血液动力学可能会揭示疾病特异性的变化.
研究的目的:
- 为了比较ONH血流变化在平行眼管在正常,初级开角玻璃眼 (POAG),和正常张力玻璃眼 (NTG) 的眼睛.
- 为了调查眼睛运动是否与健康眼睛相比,在青光眼中对ONH输液有不同的影响.
主要方法:
- 90名参与者的横截面研究 (30个正常,30个POAG,30个NTG).
- 通过激光斑点流图测量ONH的血液流量.
- 在中央视线,30度绑架和30度引进过程中进行的测量.
- 分析了总 (MA),血管 (MV) 和组织 (MT) 区域的平均模糊率 (MBR),并计算了变化比率.
主要成果:
- 在正常的眼睛中,在添加过程中,ONH血流 (MA) 显著下降.
- 与中心凝视相比,POAG眼睛在引和引过程中显示出显著的MA和MV下降.
- 与中心凝视和绑架相比,NTG眼睛在引进过程中表现出显著的MA下降.
- 在青光眼和对照组之间,ONH血流的变化比率没有显著差异.
结论:
- 水平眼导管导致ONH血液流量减少,无论是健康人群还是青光眼患者.
- 尽管观察到下降,但在眼腔导管过程中ONH血流的相对变化在正常和青光眼组之间是可比的.
- 这些发现表明,ONH对水平眼动的血管反应在POAG或NTG中没有显著改变.
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