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Updated: Jul 6, 2026

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对二次AML高度特异的突变与ELN有利风险NPM1-突变AML的ELN不利结果有关

Onyee Chan1, Najla Al Ali1, Hammad Tashkandi2

  • 1Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL.

Blood advances
|January 3, 2024
PubMed
概括

针对二次急性髓性白血病 (sMut) 特定的突变会使NPM1-突变AML患者的结果恶化. 这种不良预后甚至在有利的风险组中仍然存在,并影响整体存活率,特别是当有可测量的残留疾病存在时.

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Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase

Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...