结核病屏幕:用于结核病查的被动咳分类器,具有受控数据集.
Manuja Sharma1, Videlis Nduba2, Lilian N Njagi2
1Department of Electrical and Computer Engineering, University of Washington, 185 E Stevens Way NE, Seattle, WA 98195, USA.
Science advances
|January 3, 2024
概括
这项研究表明,分析咳声音可以帮助诊断结核病 (TB). 咳的特征有效地将结核病与其他呼吸道疾病区分开来,特别是在严重病例中.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 传染性疾病 传染性疾病
- 医疗保健中的人工智能
背景情况:
- 咳的分类显示了呼吸道疾病查的希望.
- 人们对当前模型中的偏差和数据集质量存在担忧.
- 结核病 (TB) 诊断需要改进,可访问的查方法.
研究的目的:
- 调查肺结核 (TB) 咳特征的诊断潜力.
- 开发和评估咳分类器,以区分结核病和其他呼吸道疾病.
主要方法:
- 在内罗毕,从149名肺结核患者和46名对照患者收集了被动和强迫咳的声音.
- 训练了一个ResNet18咳分类器,使用咳表图像.
- 使用五倍交叉验证验证模型,并根据细菌负载和肺腔分析性能.
主要成果:
- 咳分类器实现了0.70 (±0.11 SD) 的交叉验证灵敏度.
- 在具有较高细菌负载 (ROC-AUC:0.87) 和肺腔 (ROC-AUC:0.89) 的受试者中,模型性能显著更好.
- 消极咳的特征表明能够将结核病与非结核病患者区分开来.
结论:
- 被动咳的特征可以有效地区分结核病和其他呼吸道疾病.
- 咳的特征与结核病的细菌负担和疾病严重程度有关.
- 基于智能手机的咳分析为结核病查和诊断提供了一个潜在的工具.
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