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Updated: Jul 6, 2025

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Using the E1A Minigene Tool to Study mRNA Splicing Changes

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拼接调节剂损害了DNA损伤反应,并诱导杀死凝聚素突变MDS和AML

Emily C Wheeler1,2, Benjamin J E Martin3, William C Doyle1,2

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Science translational medicine
|January 3, 2024
PubMed
概括

骨髓发育综合征和急性骨髓性白血病中的凝聚蛋白突变预测了对拼接调节器的敏感性. 这些药物损害了DNA修复,提高了PARP抑制剂和化疗的疗效,以改善生存.

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