成年早期睡眠量和质量与中年认知功能之间的关联
Yue Leng1, Kristen Knutson1, Mercedes R Carnethon1
1From the Department of Psychiatry and Behavioral Sciences (Y.L., K.Y.), Neurology (K.Y.), and Epidemiology (K.Y.), University of California, San Francisco; Departments of Neurology (K.K.) and Preventive Medicine (M.R.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; and VA Medical Center (K.Y.), San Francisco, CA.
Neurology
|January 3, 2024
概括
中年期睡眠碎片化不良与以后更糟糕的认知功能有关. 这凸显了睡眠质量对于从中年起保持大脑健康的重要性.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 认知健康 认知健康
背景情况:
- 越来越多的证据将睡眠质量与痴呆风险联系在一起.
- 中年认知对于理解睡眠与痴呆症的关联至关重要.
- 中年期客观睡眠测量及其对认知影响的研究仍然不足.
研究的目的:
- 为了检查客观测量的睡眠时间和质量在中年和随后的认知表现之间的关联.
- 为了调查中年人的睡眠参数是否能预测11年后的认知功能.
- 在一个多元化的黑人和白人成年人群中分析这些关联.
主要方法:
- 利用手腕动图和匹兹堡睡眠质量指数 (PSQI) 来对中年人的客观和主观睡眠评估.
- 通过多项测试评估中年认知能力,包括DSST,Stroop,RAVLT,MoCA和流利性测试.
- 采用多变量逻辑回归来分析睡眠参数与认知表现差 (定义为>1 SD低于平均值) 之间的关系.
主要成果:
- 高睡眠碎片化,客观地测量,与显著增加的概率与DSST,流性和MoCA测试中的认知表现不佳有关.
- 与睡眠碎片化最高三位数的参与者相比,与最低三位数的参与者相比,认知表现差的几率是两倍以上.
- 客观睡眠时间和主观睡眠质量 (PSQI得分) 都没有与中年认知表现显著相关.
结论:
- 行为摄影测量睡眠碎片化,而不是持续时间,与中年更糟糕的认知结果有关.
- 睡眠质量是从中年开始维护认知健康的关键因素.
- 这些发现强调了解决睡眠碎片化问题对于长期大脑健康的重要性.
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