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Haiping Hu¹, Lijuan Wang¹, Jie Dou¹

¹National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.

Langmuir : the ACS journal of surfaces and colloids

|January 3, 2024

概括

这项研究开发了一种使用聚氨和酸盐释放氧化 (NO) 的涂层,以提高医疗器械的生物相容性. 该涂层表现出持续的NO释放,增强内皮质化,以及心血管植入物的抗菌特性.

科学领域:

生物材料科学生物材料科学
医疗器械涂层医疗器械涂层
纳米技术纳米技术

背景情况:

医疗器械的生物相容性对于预防不良反应至关重要.
释放氧化 (NO) 的涂层显示了提高设备性能的潜力.
现有的涂层可能缺乏持续释放或广泛适用性.

研究的目的:

开发一种新的NO释放涂层,以提高医疗器械的生物相容性.
为了研究聚氨和S-化酸涂层的性能和性能.
为了评估涂层对心血管植入物应用的潜力.

主要方法:

使用在DMSO和THF中溶解的聚氨 (PU) 和S-化 (KSNO) 制备涂层溶液.
通过溶剂蒸发诱导相分离 (SEIPS) 制造多孔涂层.
评估NO释放动力学,内皮化,细胞增殖,抗菌活性和血液兼容性.

主要成果:

涂层显示,随着阿斯科布酸的使用,NO连续释放长达200小时.
它通过促进人静脉内皮细胞 (HUVEC) 活力来加速内皮化.
该涂层抑制了人类动脉光滑肌肉细胞 (HUASMC) 的增殖,并显示出良好的抗菌和血液兼容性.

结论:

成功开发了一种基于PU和KSNO的多功能NO释放涂层.
该涂层具有出色的生物相容性,持续的NO释放,以及抗菌性质.
这种通用涂层对心血管植入物应用具有重大前景.

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...