相关实验视频

Updated: Jul 6, 2025

Ovarian Tissue Culture to Visualize Phenomena in Mouse Ovary

Ovarian Tissue Culture to Visualize Phenomena in Mouse Ovary

Published on: June 19, 2018

孕激素原始卵巢刺激与诺列酸 (NETA-PPOS) 和GNRH-抗剂协议之间的卵细胞能力是可比的:在PGT-A周期中进行的一项匹配病例对照研究

Alberto Vaiarelli¹, Danilo Cimadomo¹, Alessandro Ruffa²

¹IVIRMA Global Research Alliance, GENERA, Clinica Valle Giulia, Rome, Italy.

European journal of obstetrics, gynecology, and reproductive biology

|January 3, 2024

概括

使用诺列乙酸进行的孕激素辅助卵巢刺激 (PPOS) 在接受试管婴儿的晚期孕妇中显示出与传统的GNRH-对抗剂协议相比的卵细胞能力. 这表明PPOS是一种可行的生育保护和基因检测的替代方案.

科学领域:

生殖内分泌学生殖内分泌学
辅助生殖技术辅助生殖技术

背景情况:

传统的GnRH-对抗剂协议是辅助生殖中卵巢刺激的标准.
使用诺列乙酸 (NETA) 的孕激素辅助卵巢刺激 (PPOS) 提供了一种潜在的替代方案,在成本和患者遵守方面可能带来好处.

研究的目的:

为了比较卵细胞能力和NETA-PPOS和常规的GnRH-对抗剂协议之间的后续结果,在接受试管婴儿受精的晚龄孕妇中,进行了前植入性遗传测试,以检测化 (PGT-A).

主要方法:

一项追溯匹配病例控制研究将89名接受NETA-PPOS的妇女与178名对照进行了匹配.
两组都接受了复合FSH卵巢刺激与GnRH激动剂触发.
主要结局结果是每位第II阶段卵细胞 (每MIIEBR) 的euploid胚胎细胞发育率.

主要成果:

每个MII的EBR在NETA-PPOS和对照组 (13.9%对13.3%) 之间是可比的.
胚胎细胞形态,发育速率和经过欧化单个胚胎细胞移植后的临床结果相似.
累积活产率和新生儿结局在两组之间也是相似的.

结论:

在NETA-PPOS后的卵细胞能力与标准的卵巢刺激协议相比较.
由于潜在的成本和合规优势,NETA-PPOS是一个令人放心的选择,特别是在生育保护,PGT-A和卵细胞捐赠方面.
建议进行进一步的研究,包括随机对照试验,以证实这些发现,并探索其他结果,如卵细胞产量和围产期结果.

关键词:

这是一种GnRH-对抗剂.抑制了排卵的发生.产卵细胞的能力.这就是为什么PPOS PPOS.孕激素为原始的卵巢刺激.

更多相关视频

Extraction, Labeling, and Purification of Lineage-Specific Cells from Human Antral Follicles

Extraction, Labeling, and Purification of Lineage-Specific Cells from Human Antral Follicles

Published on: November 30, 2022

In Vitro Culture Strategy for Oocytes from Early Antral Follicle in Cattle

In Vitro Culture Strategy for Oocytes from Early Antral Follicle in Cattle

Published on: July 8, 2020

相关概念视频

Hormonal Control of the Ovarian Cycle

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...

Ovarian Cycle

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...