抗结核病宿主导治疗中的天然产品
Xuejiao Huang1, Douglas B Lowrie1, Xiao-Yong Fan1
1Shanghai Public Health Clinical Center & Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University, Shanghai 201508, China.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|January 3, 2024
概括
使用天然产品的宿主导疗法 (HDT) 通过调节宿主免疫反应,补充传统化疗以获得更好的治疗结果,为抗击结核病 (TB) 提供了一个有希望的,具有成本效益的策略.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 自然产品研究 自然产品研究
背景情况:
- 结核病 (TB) 的进展与宿主免疫有关,这表明单独的化疗可能不足以消除结核菌菌.
- 主体导向疗法 (HDT) 旨在加强宿主防御,减少炎症并提高治疗效率.
- 目前的HTT候选人面临着副作用和成本的挑战.
研究的目的:
- 审查抗结核病免疫学和HDT原则.
- 探索开发基于自然产品的高质量技术的理由和挑战.
- 总结目前对HDT药物的临床和临床前评估.
主要方法:
- 对抗结核病免疫学的文献综述.
- 对宿主导疗法概念和挑战的分析.
- 对天然产品作为结核病潜在免疫调节剂的调查.
主要成果:
- 由于其成本较低,免疫调节较温和,天然产品是合成高强度抗药物的可行替代品.
- 自然产品可以减轻与传统治疗相关的副作用和免疫病理损伤.
- 目前正在进行的研究正在评估各种自然产品在临床前和临床环境中用于结核病治疗.
结论:
- 基于天然产品的HTT具有显著的潜力,可以提高结核病治疗的疗效,并克服当前方法的局限性.
- 进一步的研究和基于目标的查对于加速发现新型结核病药物至关重要.
- 将天然产品纳入高血压治疗策略可能会导致更容易获得和更有效的结核病疗法.
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