在学龄前儿童中,产前和产后PM2.5暴露与认知和运动功能的关系
Kristina W Whitworth1, Alison M Rector-Houze2, Wei-Jen Chen3
1Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA; Center for Precision Environmental Health, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
International journal of hygiene and environmental health
|January 3, 2024
概括
在怀孕期间暴露于细颗粒物 (PM2.5) 影响产前精细和粗运动技能. 产后的PM2.5暴露会影响幼儿时期的感知表现,突出了空气质量干预的关键发育窗口.
科学领域:
- 环境健康 环境健康
- 神经发育儿科 神经发育儿科
- 流行病学 流行病学
背景情况:
- 关于微粒颗粒物 (PM2.5) 和儿童神经发育的临界暴露窗口的数据有限.
- 产前和产后早期的暴露被假设对发育中的大脑产生特别大的影响.
研究的目的:
- 评估产前和产后细颗粒物 (PM2.5) 暴露对学前儿童认知和运动功能的影响.
- 为了确定在发育过程中对PM2.5暴露效应的特定敏感时期.
主要方法:
- 在西班牙INMA研究中使用随机森林模型估计1303对母婴对的日常住宅PM2.5暴露.
- 在贝叶斯层次框架内应用分布式滞后非线性模型,以评估PM2.5对5岁左右儿童能力麦卡锡表 (MSCA) 结果的影响.
- 检查的协会每增加5μg/m3的PM2.5,汇总在统计学上显著的滞后.
主要成果:
- 产前的PM2.5暴露与精细运动技能 (1-9周) 和粗运动技能 (7-17周) 的下降有关.
- 产后的PM2.5暴露 (0.5-1.2年) 与较低的感知表现有关.
- 没有发现与一般认知指数 (GCI) 有意义的关联;一些意想不到的保护性效应被认为是以后的产后暴露.
结论:
- 儿童的运动功能容易受到子宫内PM2.5暴露,在妊娠早期发现了特定的敏感窗口.
- 生命的第一年是PM2.5暴露影响知觉表现的关键时期.
- 这些发现强调了在神经发育结果敏感的发育时期空气质量的重要性.
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