短期环境温度变化和早产发病率:系统性审查和元分析
Masoud Khosravipour1, Farideh Golbabaei1
1Occupational Health Engineering Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
International journal of hygiene and environmental health
|January 3, 2024
概括
暴露于极端寒冷和高温的变化显著增加了早产 (PTB) 的风险,特别是在温暖的季节. 这一元分析强调了环境温度和PTB发病率在出生前一周之间存在V形关联.
科学领域:
- 环境流行病学环境流行病学
- 生殖健康 生殖健康
- 围产儿医学 围产儿医学
背景情况:
- 环境温度变化越来越多地被认为是环境压力因素.
- 以前的研究表明,温度极端和不良妊娠结果之间存在联系.
- 温度变化对早产 (PTB) 的具体短期影响需要进一步阐明.
研究的目的:
- 确定环境温度变化对早产发病率 (PTB) 的短期影响.
- 为了分析这些影响,跨越单个和累积的延迟日,直到出生前一周.
- 通过百分点和线性元分析方法来研究这种关联.
主要方法:
- 在Web of Science,PubMed和Scopus上进行了系统的文献搜索.
- 包括39项观察性研究,涵盖了1250万例怀孕和70万例PTB病例.
- 使用百分位元分析 (比较温度百分位) 和线性元分析 (每5°C增量).
主要成果:
- 极度寒冷 (P1在滞后0点) 和高温 (P95,P99在滞后1点和滞后0-6点) 都与增加PTB风险有关.
- 滞后0-6的温度增加5°C显示了合并的RR为1.038 (95%CI:1.018,1.058).
- 在温暖的季节 (RR=1.082) 观察到显著的关联,但在寒冷的季节没有;风险在滞后1.0时达到顶峰.
结论:
- 在环境温度水平和PTB发病率之间存在V形非线性关联.
- 温度升高和从中等水平降低都会增加PTB风险.
- 对怀孕期间职业热/寒暴露的进一步研究是有必要的.
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