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Updated: Jul 6, 2025

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来自TAMC的肌酸可以维持质母细胞瘤的生长

Huiwen Yan1, Pengcheng Bu1

  • 1Key Laboratory of Epigenetic Regulation and Intervention, Chinese Academy of Sciences, Beijing 100101, China; Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

Cell metabolism
|January 3, 2024
PubMed
概括

瘤相关髓状细胞 (TAMCs) 靠近缺氧质母细胞瘤 (GBM) 区域提供肌酸. 这促进了瘤细胞的生长,促进了GBM的进展,并突出了新的治疗点.

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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