氨基酸代谢和动脉样硬化心血管疾病
Sumit Kumar Anand1, Theresea-Anne Governale2, Xiangyu Zhang3
1Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana.
The American journal of pathology
|January 3, 2024
概括
氨基酸代谢显著影响动脉样硬化心血管疾病 (ASCVD) 的发展. 了解这些代谢途径为诊断和治疗ASCVD提供了新的途径,ASCVD是全球主要的死亡原因.
科学领域:
- 生物化学 生化学
- 心血管医学 心血管医学
- 代谢学 代谢学 代谢学
背景情况:
- 动脉样性心血管疾病 (ASCVD) 仍然是全球主要的死亡原因.
- 不调节的脂质代谢是ASCVD的关键驱动因素,但目前的治疗方法不足.
- 新出现的证据将氨基酸代谢与包括ASCVD在内的各种疾病状态联系起来.
研究的目的:
- 审查当前对氨基酸代谢在ASCVD中的作用的理解.
- 在氨基酸路径中识别潜在的生物标志物,致病因素和治疗点.
- 探索氨基酸调节失调在ASCVD病变发生过程中的影响.
主要方法:
- 文献综述侧重于氨基酸代谢和ASCVD.
- 对研究特定氨基酸 (氨酸,分支链氨基酸,甘氨酸,芳香氨基酸) 和其代谢物的研究进行分析.
- 综合证据,将氨基酸代谢与ASCVD特征联系起来.
主要成果:
- 特定的氨基酸如氨酸,分支链氨基酸,甘氨酸和芳香氨基酸都与ASCVD有关.
- 氨基酸代谢物,如homoarginine和多氨酸与ASCVD有关.
- 不调节的氨基酸代谢有助于ASCVD中脂肪代谢受损,内皮功能障碍,炎症和死核形成.
结论:
- 氨基酸代谢是ASCVD的一个关键,但被低估的因素.
- 准氨基酸通路可能为ASCVD提供新的诊断和治疗策略.
- 需要进一步的研究来阐明连接氨基酸代谢和ASCVD的精确机制.
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