常见感染中的NSAID处方和不良结果:基于人口的队列研究
Beth Stuart1,2, Roderick Venekamp3, Hilda Hounkpatin2
1Wolfson Institute of Population Health, Queen Mary University of London, London, UK b.l.stuart@qmul.ac.uk.
BMJ open
|January 3, 2024
概括
在初级保健中为呼吸道或泌尿道感染处方的非类固醇抗炎药物 (NSAIDs) 与更高的住院率和死亡率有关. 这表明NSAID的使用可能会使急性感染的结果恶化,因此需要谨慎的处方.
科学领域:
- 初级医疗保健医学 一级医疗保健医学
- 传染性疾病 传染性疾病
- 药物监督 药物监督 药物监督
背景情况:
- 非类固醇抗炎药物 (NSAIDs) 通常用于初级保健机构的感染.
- 使用NSAID与呼吸道感染 (RTIs) 和尿路感染 (UTIs) 的不良结果之间的关联需要进一步调查.
研究的目的:
- 评估NSAID处方与RTIs或UTI患者在初级保健中的不良结果之间的关联.
- 为了确定NSAID使用是否会增加这些常见感染后住院或死亡的风险.
主要方法:
- 一项使用电子健康记录的队列研究,来自英国87家全科医院.
- 包括142,925名咨询RTI或UTI的患者.
- 分析了在咨询后30天内住院或死亡,使用Poisson模型调整了个人和实践层面的多个混因素.
主要成果:
- NSAID处方与RTIs和UTI的住院/死亡风险增加有关.
- 急性NSAID处方显示RTIs的RR为2.73和UTI的RR为3.03.
- 实践层面的分析表明,NSAID处方率每增加一个百分点,住院/死亡率增加0.32个百分点.
结论:
- 在初级保健中,对RTIs和UTIs的NSAID处方,虽然不常见,但可能与住院的风险增加有关.
- 这些发现支持现有数据,表明NSAIDs可能与急性感染后的较差结果有关.
- 建议在给RTI或UTI患者开NSAID时谨慎使用.
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