果汁与药物相互作用的幅度由于度依赖的液体分泌:果,子和葡萄汁之间的差异
Miyuki Takemura1,2, Katsuhisa Inoue2, Ikumi Tamai1
1Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.
Biological & pharmaceutical bulletin
|January 3, 2024
概括
饮料度会影响胃肠液体体积,影响药物吸收. 比如果汁 (AJ) 等高度的果汁会增加液体,减少药物吸收,而低度的葡萄汁 (GFJ) 的影响较小.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 药物相互作用 药物相互作用
背景情况:
- 胃肠道 (GI) 液体体积受溶液度的影响.
- 这种依赖于度的流体转移可能会影响饮料与药物相互作用.
- 果汁具有不同的透性,可能会以不同的方式影响药物吸收.
研究的目的:
- 调查是否依赖于度的液体分泌解释了不同果汁与药物相互作用的大小.
- 为了比较葡萄汁 (GFJ),汁 (OJ) 和果汁 (AJ) 对肠道液体体积和药物药理学的影响.
- 为了确定药物透性是否影响饮料度对吸收的影响.
主要方法:
- 在老鼠体内的闭环技术,用于测量饮料后肠液的运动.
- 在净化水和各种水果汁中口服阿提诺洛尔 (低透性药物) 和抗皮林 (高透性药物).
- 血药物度的药理动力学分析.
主要成果:
- 肠液体体积按照排名顺序进行:AJ > OJ > GFJ > 净化水,与饮料度相关 (AJ: 749 mOsm/kg,OJ: 686 mOsm/kg,GFJ: 552 mOsm/kg).
- 血中阿提诺洛尔度在水中最高,其次是GFJ和OJ,在AJ中最低.
- 抗皮林的血度在饮料之间没有显著差异,这表明对高透性药物的影响较小.
结论:
- 饮料度的差异有助于饮料与药物相互作用的不同程度.
- 消化道中依赖于度的液体转移会影响低透性药物的吸收.
- 饮料度是理解和预测饮料与药物相互作用的重要因素.
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