[超硫化物调节电友应力]
Masahiro Akiyama1, Jun Uchiyama1, Yoshito Kumagai2
1Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
|January 3, 2024
概括
转录因子Nrf2和cystathionine γ-lyase (CSE) 对环境电友进行保护. 肠道细菌产生超硫化物,提供对电友毒性的保护.
科学领域:
- 生物化学 生物化学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 环境中的电友因修改蛋白质醇而损害细胞功能,增加疾病风险.
- Nrf2途径可以排毒电友,而超硫化物如氨酸硫化物 (CysSSH) 可以捕获它们.
- 在减轻电毒性方面,Nrf2和CSE的作用尚未完全理解.
研究的目的:
- 调查Nrf2和CSE在保护环境电毒性方面的单独和联合作用.
- 探索肠道微生物群对超硫化物生产和对电友应激的保护的贡献.
主要方法:
- 使用了Nrf2淘汰赛 (KO),CSE KO和Nrf2/CSE双 KO (DKO) 的小鼠模型.
- 在不同的KO小鼠系中评估了对环境电友的敏感性.
- 分析了无菌和传统养小鼠的血中超硫化物水平.
- 确定了负责CysSSH生产的特定肠道细菌家族.
主要成果:
- 与单个KO小鼠相比,CSE/Nrf2 DKO小鼠对电友的敏感性增加,这表明它们具有不同的保护机制.
- 缺乏肠道微生物群的小鼠显示血中超硫化物水平降低.
- 罗米诺科卡科和拉克诺斯皮拉科家族被确定为高CysSSH生产者.
结论:
- Nrf2和CSE通路对于减轻环境电毒性至关重要.
- 肠道微生物群是内源超硫化物的重要来源.
- 来自肠道的超硫化物可能会保护宿主免受环境电友性暴露.
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