维生素A营养状况和COVID-19中的临床结果:系统性审查
Iara Katrynne F Oliveira1, Vanessa C Carvalho1, Gabriela S Santos1
1Federal University of Piauí.
维生素A缺乏可能会使COVID-19的结果变得更糟. 研究发现,2019年严重的冠状病毒病 (COVID-19) 的住院患者的视网膜醇水平较低,这表明维生素A状态和疾病严重程度之间存在联系.
科学领域:
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 维生素A (视网醇) 对肺和免疫功能至关重要.
- 新型冠状病毒疾病2019 (COVID-19) 显著影响病率和死亡率.
- 维生素A在COVID-19病理生理学中的作用需要阐明.
研究的目的:
- 评估COVID-19患者的维生素A营养状况和临床结果之间的关系.
- 审查COVID-19患者住院患者的视网醇水平的观察性研究.
主要方法:
- 在PubMed,Web of Science,Scopus和ScienceDirect数据库中的系统文献搜索.
- 包括观察性研究评估COVID-19患者的视网醇水平.
- 按照PRISMA指南进行研究选择和数据提取.
主要成果:
- 七项研究符合1912篇最初识别的文章的纳入标准.
- 四项研究将边界或缺乏的视网醇水平 (<0.70mol/L) 与更糟糕的COVID-19结局联系起来.
- 三项研究发现,与无症状或康复期患者相比,有症状的COVID-19患者的维生素A水平平均较低.
结论:
- 维生素A状态和COVID-19临床结果之间存在潜在的关联.
- 需要进一步的临床试验来确认维生素A在COVID-19中的作用.
- 维持足够的维生素A水平可能对管理COVID-19严重程度很重要.
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