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Updated: Jul 6, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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基于预先训练的蛋白质语言模型和对比学习的蛋白质-DNA结合部位预测

Yufan Liu1, Boxue Tian1

  • 1MOE Key Laboratory of Bioinformatics, State Key Laboratory of Molecular Oncology, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.

Briefings in bioinformatics
|January 3, 2024
PubMed
概括

一种新的计算方法,对比学习和预训练编码器 (CLAPE),准确地预测DNA结合残留物. 蛋白质-DNA相互作用建模的这一进步为生物技术和药物设计提供了潜力.

关键词:
相反的学习学习学习.预先培训的培训前培训蛋白DNA相互作用

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