多模式自发大脑活动的测量揭示了皮质功能组织的共同和分歧模式
Hadi Vafaii1, Francesca Mandino2, Gabriel Desrosiers-Grégoire3,4
1Department of Physics, University of Maryland, College Park, MD, 20742, USA. vafaii@umd.edu.
Nature communications
|January 3, 2024
概括
成像揭示了小鼠的重叠功能性大脑网络,类似但与fMRI-BOLD信号不同. 这项研究强调了跨模式的共享和独特的网络属性.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 大规模的功能性大脑网络通常使用动物和人类的fMRI-BOLD信号进行研究.
- fMRI-BOLD信号与潜在的神经活动之间的准确关系仍然很复杂,并未完全理解.
- 现有的研究通常假定功能性大脑网络是不连接的,区域只属于一个网络.
研究的目的:
- 在小鼠中使用同时的Ca2+成像和fMRI-BOLD研究功能性大脑网络的重叠组织.
- 为了比较来自Ca2+信号和fMRI-BOLD信号的网络结构.
- 测试功能网络表现出混合成员组织的假设.
主要方法:
- 在小鼠中同时进行广场Ca2+成像 (GCaMP6f) 和fMRI-BOLD.
- 应用混合成员算法来识别从两种模式的皮质网络.
- 分析Ca2+和BOLD信号之间的网络重叠,相似性和差异.
主要成果:
- 在Ca2+成像和fMRI-BOLD数据中观察到显著的网络重叠.
- Ca2+成像检测到多个类似于BOLD的网络,低频Ca2+信号与BOLD网络相似.
- 功能连接的主要梯度在Ca2+和BOLD信号之间高度一致,尽管连接强度和多样性的模式特定差异.
结论:
- Ca2+成像揭示了老鼠的功能性皮质组织的重叠.
- 这个组织与fMRI-BOLD信号共享了几个特性,但也表现出不同的特征.
- 这些发现提供了关于不同神经成像模式和大脑网络结构之间的关系的见解.
相关概念视频
01:21Association Areas of the Cortex
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
01:13Functional Brain Systems: Reticular Formation
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...