暴露于空气污染和卵巢储备参数
Katarzyna Wieczorek1, Dorota Szczęsna2, Michał Radwan3,4
1Department of Chemical Safety, Nofer Institute of Occupational Medicine, 8 Teresy St; 91-348, Łódź, Poland. katarzyna.wieczorek@imp.lodz.pl.
Scientific reports
|January 3, 2024
概括
空气污染,特别是细颗粒物 (PM2.5) 和二氧化硫 (SO2),对女性的卵巢储备产生负面影响. 暴露与降低抗米勒尔激素 (AMH) 和毛囊数 (AFC) 相关,这是关键的生育指标.
科学领域:
- 环境健康 环境健康
- 生殖内分泌学 生殖内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 空气污染是心血管和呼吸系统疾病的已知危险因素.
- 现有研究强调了空气污染和男性生育能力之间的联系.
- 对空气污染对女性生育能力,特别是卵巢储备的影响的研究是有限的.
研究的目的:
- 调查波兰妇女环境空气污染暴露与卵巢储备参数之间的关联.
- 评估特定空气污染物对卵巢储备的关键指标的影响.
主要方法:
- 这项研究包括511名参加不孕症诊所的妇女.
- 通过人口统计,生活方式和健康问题问卷收集的数据.
- 卵巢储备通过腹膜毛囊数 (AFC) 和激素水平 (AMH,FSH,E2) 来评估.
- 从国家环境保护督察局获得的空气污染物数据 (PM2.5,PM10,SO2,NOx,CO,O3).
主要成果:
- 在PM2.5暴露和AMH (p=0.032) 和AFC (p=0.044) 之间发现了显著的负相关性.
- SO2度与AFC (p=0.038) 的降低有关.
- 在女性因子不孕症患者中,PM10,PM2.5和SO2对AFC的负面影响更为明显.
- 在35岁以上的女性中,PM2.5和NOx暴露对AFC和AMH产生了更大的负面影响.
结论:
- 空气污染,特别是PM2.5和SO2,可以通过降低AFC和AMH水平来减少卵巢储备.
- 研究结果表明,空气污染对女性生育潜力的负面影响.
- 需要进一步的研究来阐明机制和长期影响.
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