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Updated: Jul 6, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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在AD/PD病理生理学中对BRCA1和Ube2k的RING域突变体进行模拟和计算研究

Mehar Sahu1, Neetu Rani1, Pravir Kumar2

  • 1Molecular Neuroscience and Functional Genomics Laboratory, Department of Biotechnology, Delhi Technological University (Formerly Delhi College of Engineering), Shahbad Daulatpur, Bawana Road, Delhi, 110042, India.

Molecular biotechnology
|January 3, 2024
PubMed
概括

这项研究确定BRCA1是关键的E3结合酶,与阿尔茨海默氏症和帕金森病有关. 它的RING域中的突变,特别是K32L,破坏了它的功能和与Ube2k的相互作用,可能加速神经退行.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.这就是BRCA1的原因.突变突变是一种突变.神经退行发生神经退行.帕金森病是帕金森氏症的一种疾病.在RING域名域名中.在Ubiquitination中使用.

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