与结石患者的系统代谢相关的口腔和肠道微生物结构的差异
Zi-Jie Xu1, Lei Chen1, Qi-Lin Tang1
1Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100, Haining Road, Hongkou District, Shanghai, 200080, China.
World journal of urology
|January 3, 2024
概括
石疾病与口腔和肠道细菌的变化有关. 尿酸结石患者表现出改变的微生物组和新陈代谢,这表明这些微生物在结石形成中的作用.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 石病 (KSD) 的发病过程很复杂.
- 口腔和肠道微生物组与KSD系统代谢之间的相互作用尚未完全理解.
研究的目的:
- 研究口腔和肠道微生物组在不同类型的结石疾病中与系统代谢和临床参数有关的作用.
主要方法:
- 一项病例对照研究分析了来自76名参与者的便,唾液,尿液和血清样本的16SrRNA和非向代谢学结果 (15个尿酸石头,41个酸盐石头,20个对照).
- 通过Spearman的分析确定了相关性.
主要成果:
- 尿酸结石患者表现出口腔和肠道微生物组丰富性和多样性的减少.
- 在尿酸结石患者中观察到改变的微生物组成 (例如,较低的Bacteroides,较高的Porphyromonas) 和代谢途径 (氨基酸,脂肪酸).
- 微生物组和新陈代谢与低水摄入量和尿液pH相关,预测模型显示AUC> 0.85.
结论:
- 口腔和肠道微生物组的结构和组成在不同类型的结石疾病中存在差异.
- 口腔/肠道微生物群,新陈代谢和临床参数之间的关联表明微生物群在结石疾病中起着重要作用.
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