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Updated: Jul 6, 2025

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
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在哺乳动物细胞中进行翻译调节和治疗生物计算的工程聚甲基替代物

Jiawei Shao1,2,3,4, Shichao Li5, Xinyuan Qiu6

  • 1International Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China. jiaweishao@zju.edu.cn.

Cell research
|January 3, 2024
PubMed
概括

科学家们开发了一种可编程的基因调节策略,用于控制蛋白质生产. 这种方法使用合成因子来精确管理基因表达,为体内基因疗法和疾病治疗提供了新的可能性.

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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