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在Th17细胞中,STAT3和SOX-5诱导BRG1介导的RORCE2的染色体重塑

Xian Wang1,2, Chao Han1, Di Yang1

  • 1Institute of Immunology, Third Military Medical University (Army Medical University), 400038, Chongqing, People's Republic of China.

Communications biology
|January 3, 2024
PubMed
概括

STAT3和SOX-5通过与RORCE2增强剂结合来激活RORγt基因表达. 这一过程对于T辅助17细胞的分化和实验性自身免疫脑膜炎的发展至关重要.

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