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致癌激活EEF1A2表达:从假定的致癌基因到已确定的致癌基因的旅程

Saket Awadhesbhai Patel^1,2, Md Khurshidul Hassan^1,2, Manjusha Dixit^3,4

¹School of Biological Sciences, National Institute of Science Education and Research, Room No. 204, P.O. Jatni, Khurda, Bhubaneswar, Odisha, 752050, India.

Cellular & molecular biology letters

|January 3, 2024

概括

细胞延长因子1α2 (EEF1A2) 是一个关键的翻译因子,当异常表达时,它起着瘤基因的作用. 这篇综述详细介绍了EEF1A2的细节.

科学领域:

分子生物学分子生物学
在瘤学瘤学.
生物化学生物化学

背景情况:

翻译因子,传统上被视为管家,越来越多地被认为是它们在细胞生长,细胞亡和瘤形成中的作用.
细胞延长因子1α2 (EEF1A2) 是一个转化因子,对于将氨基酸tRNA输送到核糖体至关重要.
与其无处不在的异型EEF1A1相比,EEF1A2表现出明显的组织分布,其异常表达与瘤转化有关.

研究的目的:

审查EEF1A2作为癌基因在癌症发展中的作用.
在七种癌症类型中收集EEF1A2过度表达的证据.
探索EEF1A2在癌症中的分子机制,信号通路和治疗潜力.

主要方法:

文献综述汇编了报告在各种癌症中过度表达EEF1A2的研究.
对异常EEF1A2表达对细胞致癌性质的影响分析.
调查EEF1A2的交互伙伴和受影响的信号通路.

主要成果:

在多个固体瘤中经常观察到EEF1A2过度表达.
异常的EEF1A2表达影响瘤性质,细胞信号和蛋白质相互作用.
作为癌症治疗中的治疗标,EEF1A2显示出显著的潜力.

结论:

EEF1A2作为瘤基因起作用,通过其异常表达为瘤发生作出贡献.
了解EEF1A2的分子机制和相互作用对于癌症治疗的发展至关重要.
对于各种癌症,EEF1A2是一个有前途的治疗标.

关键词:

在 AKT AKT 里面.癌症癌症癌症癌症 EEF1A1A1EEF1A1EEF1A1EEF1A1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1EEF1E1EF1E1EF1E1EF1E1EF1E1EF1EF1E1EF1EF1EF1EF1EF1EF1EF1EF1EF1EF1EF1EF1EF1EF1EF1EF1 EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1A2EEF1E1E1E1E2E2E2E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1E1 在PI3K中,PI3K是指PI3K.

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