三糖-葡萄糖指数基线与老年人口中发生心血管疾病的轨迹之间的关系
Yue Wang1, Xueyu Chen2, Jie Shi2
1Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, No. 44 Wenhua West Road, Jinan, 250012, Shandong, China.
高基线甘油三糖 (TyG) 指数和不断增加的TyG轨迹预测了老年人心血管疾病 (CVD) 风险. 这些发现强调了TyG指数作为老年人心血管疾病预防策略的关键指标.
科学领域:
- 内分泌学和新陈代谢学
- 心血管研究研究心血管研究
- 老年医学 老年医学
背景情况:
- 甘油三糖 (TyG) 指数是胰岛素抵抗和心血管疾病 (CVD) 风险的公认生物标志物.
- 之前的研究没有全面评估基线TyG指数及其与老年人群中心血管疾病发展相关的纵向轨迹.
研究的目的:
- 调查基线甘油三糖 (TyG) 指数水平及其多个时间点轨迹与心血管疾病及其亚型在老年人队列中的发生率之间的关联.
- 评估不同TyG指数模式对老年人心血管事件的预测价值.
主要方法:
- 从2016年到2022年,分析了20185名老年参与者的队列.
- 三甲糖-葡萄糖 (TyG) 指数是使用禁食三甲糖和葡萄糖水平来计算的.
- 隐性类轨迹模型 (LCTM) 确定了TyG指数模式,而Cox比例危险模型评估了心血管疾病风险.
主要成果:
- 较高的基线TyG指数四分位数与心血管疾病风险增加显著相关 (aHR:1.28,95% CI:1.19-1.39).
- 确定了五种不同的TyG指数轨迹;中等稳定和高渐进增长模式与低渐进增长组相比显示心血管疾病风险增加 (aHRs: 1.17-1.25).
- 在TyG指数轨迹和CVD亚型之间发现了类似的关联.
结论:
- 升高的基线甘油三糖 (TyG) 指数和特定的纵向轨迹 (中等稳定,高逐步增加) 与老年人患心血管疾病的风险更高有关.
- TyG指数及其动态变化是评估老年人群心血管风险的有价值指标.
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