在一般人群中,身体脂肪百分比和心脏代谢疾病之间的关联
Jiayi Si1, Lina Kang1,2, Yihai Liu2
1Department of Cardiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.
Endocrine, metabolic & immune disorders drug targets
|January 4, 2024
概括
较高的体脂百分比显著增加了患心脏代谢疾病的风险,包括心血管疾病,高血压和糖尿病. 这一发现突出了身体脂肪百分比作为这些疾病的关键预测因素.
科学领域:
- 代谢健康 代谢健康
- 心血管研究研究心血管研究
- 肥胖研究 肥胖研究
背景情况:
- 身体脂肪百分比是代谢健康和炎症的关键指标.
- 了解其与心脏代谢疾病的关联对于公共健康至关重要.
- 以前的研究表明存在联系,但需要对一般人群进行进一步的分析.
研究的目的:
- 调查身体脂肪百分比与心脏代谢疾病风险之间的关联.
- 在一个大而多样化的普通人口样本中分析这种关系.
- 确定身体脂肪百分比作为疾病风险的潜在预测因素.
主要方法:
- 追溯的横截面研究设计.
- 利用了5084名参与者的数据 (1999-2004年全国健康和营养检查调查).
- 通过生物电阻分析测量身体脂肪百分比;通过问卷和检查确定心脏代谢疾病 (心血管疾病,高血压,糖尿病). 用于分析的多变量逻辑回归.
主要成果:
- 与最低四分位数相比,体脂百分比最高的四分位数显示心血管疾病 (3.99),高血压 (1.08) 和糖尿病 (3.08) 的几率比率显著增加.
- 当被分析为连续变量时,身体脂肪百分比独立预测了心脏代谢疾病的风险增加.
- 观察到剂量-反应关系,较高的体脂水平与较高的疾病风险相关.
结论:
- 身体脂肪百分比升高与患心脏代谢疾病的可能性更高密切相关.
- 身体脂肪百分比是心血管疾病,高血压和糖尿病的强大和独立预测因素.
- 公共卫生战略应将体脂百分比作为预防心脏代谢疾病的目标.
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