相关实验视频

Updated: Jul 6, 2025

Isolated Pancreatic Islet Treatment and Apoptosis Measurement

Isolated Pancreatic Islet Treatment and Apoptosis Measurement

Published on: May 2, 2025

抗糖尿病的皮尼托尔可以改善受损的纤维细胞

Ji-Yong Jung¹, Joong Hyun Shim², Su Hae Cho³

¹Amorepacific Corporation R&D Center, Yongin 17074, Republic of Korea.

Biomolecules & therapeutics

|January 4, 2024

概括

皮尼托尔是一种具有抗糖尿病特性的化合物,对皮肤健康有很大的前景. 它有助于伤口愈合,并通过保护原蛋白和调节关键信号通路来保护抗紫外线A (UVA) 损伤.

科学领域:

皮肤病学皮肤病学
生物化学生物化学
分子生物学分子生物学

背景情况:

皮尼托尔 (3-O-Methyl-D-chiro-inositol) 已知具有类似胰岛素的作用和抗糖尿病特性.
它对皮肤的有益作用,特别是关于光损伤的益处,尚未得到充分证实.

研究的目的:

研究皮尼托对暴露于紫外线A (UVA) 的人体皮肤纤维细胞 (HDF) 和人体皮肤等效物 (HDEs) 的影响.
探索pinitol作为治疗皮肤光损伤的治疗剂的潜力.

主要方法:

HDF和HDE暴露于UVA辐射的情况.
评估伤口愈合,矩阵金属蛋白酶1 (MMP1), I型原体和金属蛋白酶1 (TIMP1) 组织抑制剂的水平.
电子显微镜用于原纤维分析.
西方涂抹分析ERK,JNK,p38和Smad3酸化.

主要成果:

皮尼托尔增强了UVA损坏的HDF中的伤口愈合.
皮尼托尔抵消了UVA诱导的MMP1上调和HDE中的原体I型/TIMP1下调.
皮尼托尔增加了UVA照射的HDE中的原纤维的规律性.
皮尼托尔调节的UVA诱导ERK,JNK和Smad3的酸化,表明TGF-β信号的参与.

结论:

皮尼托尔显示出对抗紫外线引起的皮肤损伤的保护作用.
皮尼托尔促进了原蛋白的合成和伤口愈合.
皮尼托尔可以作为与光损伤相关的皮肤疾病的治疗剂.

关键词:

原蛋白是一种原蛋白.纤维细胞母细胞细胞.皮尼托尔 (3-O-甲基-D-奇罗-伊诺西托尔) 是一种信号传输信号传输紫外线A 紫外线A

更多相关视频

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Published on: December 2, 2022

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

相关概念视频

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...

Introduction to Fibroblasts

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...