结肠过境反应与自我报告的饮食之间的关系 便秘患者的便秘严重程度 根据表型
David Deutsch1, Michel Bouchoucha1,2, Julien Uzan1
1Department of Gastroenterology, Hôpital Avicenne, Bobigny, France.
便秘的严重程度与功能性便秘和排便障碍患者的结肠过渡反应与饮食有关,但与便秘的刺激性肠综合征无关. 这突显了表型特异性的差异,即饮食如何影响便秘的肠道运动.
科学领域:
- 胃肠病学 胃肠病学
- 消化系统生理学 消化系统生理学
- 临床营养学 临床营养学
背景情况:
- 饮食是胃肠机动性和分泌物的主要调节者.
- 了解感知到便秘的严重程度与肠道对食物的反应之间的关系对于管理慢性便秘至关重要.
研究的目的:
- 调查慢性异常性便秘患者的自我感知便秘严重程度 (CS) 和结肠过境对饮食反应 (CTRE) 之间的相互作用,按表型分层.
- 为了确定CS是否与不同便秘亚型的饮食后结肠运动变化相关.
主要方法:
- 参与了387名患有罗马四号慢性异常性便秘的门诊患者.
- 收集的数据包括CS,疼痛,胀气,抑郁,焦虑,总和细分结肠过境时间 (CTT) 和CTRE的利克尔特尺度.
- 患者被分为便秘 (IBS-C),功能性便秘 (FC) 和排便障碍 (DD) 的刺激性肠综合征.
主要成果:
- 女性患者 (83%) 报告说,发胀增加,便形状发生变化.
- 在IBS-C和FC中,CS与膨胀严重程度和总CTT相关.
- 在IBS-C中,CS也与腹部疼痛和便形式有关. 在FC中,CS与左侧CTRE相关. 在DD中,CS与总CTT相关,并离开CTRE.
结论:
- 对饮食的结肠过渡反应与IBS-C患者的CS无关.
- 在功能性便秘和排便障碍患者中,左侧结肠过渡反应与饮食 (CTRE) 与便秘严重程度有显著的关联.
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