肝炎C感染患者的细胞因子,有或没有阿片类药物维持治疗
Kristin Nygaard-Odeh1,2, Hedda Soloy-Nilsen1,2, Magnhild Gangsoy Kristiansen1,2
1Nordland Hospital Trust, Bodoe, Norway.
Acta neuropsychiatrica
|January 4, 2024
概括
慢性型肝炎病毒 (HCV) 感染和阿片类药物使用会改变细胞因子水平. 这项研究发现,在接受阿片类药物维持治疗的HCV患者中,对周围循环细胞因子的影响最小.
科学领域:
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
- 成 药物 药物 药物 药物
背景情况:
- 已知慢性型肝炎病毒 (HCV) 感染和阿片类药物使用会影响细胞因子概况.
- 以前的研究已经检查了在阿片类药物维持治疗的患者中选择的细胞因子.
- 关于同时接受阿片类药物维持治疗的HCV患者的综合性细胞因子概况的数据有限.
研究的目的:
- 为了研究患有活跃HCV感染的患者的外周循环细胞因子概况.
- 为了比较HCV患者与没有阿片类药物维持治疗之间的细胞因子水平.
主要方法:
- 对120名门诊患者进行的横截面研究,这些患者被转诊接受HCV治疗.
- 使用多重技术测量血清细胞因子水平 (27个分析物).
- 通过采访和病史收集的数据;进行非参数和回归分析.
主要成果:
- 120名患者中有53人接受了阿片类药物维持治疗 (中位数为68.4个月).
- 在阿片类药物维持组中,介质素-1β (IL-1β) 的含量较低,而eotaxin-1 的含量较高.
- 两组之间其他测量细胞因子水平没有显著差异.
结论:
- 慢性阿片类药物给药对HCV感染患者的外周循环细胞因子水平的影响很小.
- 观察到的IL-1β和eotaxin-1的变化需要在HCV和阿片类药物使用的背景下进行进一步的研究.
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