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相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Preventive Healthcare Services01:30

Preventive Healthcare Services

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
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Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

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Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
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Applications of GIS: Disaster Management and Emergency Response01:29

Applications of GIS: Disaster Management and Emergency Response

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Geographic Information System (GIS) technology is essential for risk identification, action prioritization, and resource optimization in critical situations like flooding and earthquakes. By integrating spatial and demographic data, GIS provides a comprehensive framework for emergency response.GIS integrates data layers, like rainfall intensity, topography, elevation profiles, and river levels, to model high-risk flood zones. These layers assess areas susceptible to flooding based on their...
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相关实验视频

Updated: Jul 6, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

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利用GWAS:通往预防的道路?

Stacey J Winham1, Mark E Sherman2

  • 1Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.

Cancer prevention research (Philadelphia, Pa.)
|January 4, 2024
PubMed
概括

利用基因变异来拦截癌症对预防有希望. 然而,在理解风险复杂性和证明有效药物策略的功能效应方面,仍然存在重大挑战.

科学领域:

  • 在瘤学瘤学.
  • 遗传学 遗传学 是一个
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 新的癌症预防药物策略对于降低死亡率至关重要.
  • 识别与癌症风险相关的常见遗传变异为癌症拦截提供了潜力.
  • 针对因果遗传变异可能会显著影响癌症预防.

研究的目的:

  • 探索利用遗传发现来拦截癌症的潜力.
  • 确定和讨论开发基因变异向癌症预防策略的障碍.

主要方法:

  • 文学综述和对癌症遗传风险因素的概念分析.
  • 评估将遗传发现转化为临床预防策略的挑战.
  • 对基于基因的癌症拦截现有前景的评估.

主要成果:

  • 常见的遗传变异会使癌症风险略微增加.
  • 存在重大障碍,包括理解风险复杂性,对二进制结果的统计能力,前体特征,癌症异质性,生命过程影响,基因环境相互作用以及证明功能影响.

结论:

  • 虽然针对因果基因变异进行癌症拦截是一个有希望的概念,但必须解决一些重大挑战.

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  • 需要进一步的研究来克服这些障碍,并实现基于基因的癌症预防药物的全部潜力.