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具有增强的抗菌和抗粘性活性的含聚乙烯聚氨,用于对抗导管诱导的感染

Yang Zhang¹, Guangbin Song¹, Can Hu¹

¹School of Chemistry and Chemical Engineering, Tianjin University of Technology Tianjin China wangliang@tjut.edu.cn wang0549@e.ntu.edu.sg.

|January 4, 2024

概括

与银纳米颗粒混合的新型 perfluoropolyether-incorporated 聚氨有效防止医疗器械上的细菌附着和生物膜形成. 这为减少导管诱导的感染提供了一个有希望的解决方案.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
预防传染病预防传染病

背景情况:

细菌附着在聚氨 (PU) 医疗器械上会导致感染.
开发具有杀菌性和抗粘附性质的材料对于生物医学应用至关重要.

研究的目的:

设计和评估与银纳米粒子 (AgNPs) 混合的新型 perfluoropolyether-incorporated 聚氨 (PFPU).
为医疗器械制造具有增强抗菌和抗粘合能力的双功能PFPU/AgNPs复合材料.

主要方法:

合成的PFPU材料含有多种多聚乙烯 (PFPE) 含量.
通过溶剂造制造的PFPU/AgNPs薄膜 (PFPU/Ag-F).
评估了对黄金葡萄球菌和大肠杆菌的抗菌活性.
使用连续流动的人造尿模型,对PU导管上的PFPU/AgNPs涂层的抗粘附性能进行了评估.

主要成果:

含有8mol%PFPE的PFPU8/Ag-F显示出最佳的疏水性和机械性能.
在30分钟内,PFPU8/Ag-F有效地消灭了99.9%以上的金黄色细菌和大肠杆菌.
在人工尿模型中,PFPU8/Ag涂层在8天的时间内显示出显著的抗细菌粘附性.

结论:

含有PFPE的PFPU/AgNPs复合材料具有强大的杀菌和抗粘合性能.
这些材料显示出在医疗植入物上防止细菌殖民和生物膜形成的潜力.
开发的涂层可以减少与导管等器件相关的术后感染的发生率.

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