在非关节炎前部缺血光学神经病变中,周周膜冠状血管和视觉相关物使用扫描源光学连贯断层扫描
Edward S Lu1,2,3, Raviv Katz1,2,3, John B Miller1,2,3
1Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, United States.
Frontiers in ophthalmology
|January 4, 2024
概括
与对照组相比,非动脉炎前面缺血性视觉神经病变 (NAION) 患者的周围状体较厚,胸腔血管度指数 (CVI) 较低. 非急性NAION中的视觉功能与CVI相关,这表明胆道变化和视力丧失之间存在联系.
科学领域:
- 眼科医生 眼科 眼科
- 神经眼科神经眼科
- 血管生物学 血管生物学
背景情况:
- 周皮带与视神经的接近性表明它与非动脉炎前面缺血性视神经病变 (NAION) 有关.
- 在NAION中,先前对周周膜胆道厚度 (PCT) 和胆道血管度指数 (CVI) 的研究已经产生了不一致的结果.
- 在NAION中,PCT,CVI和视觉功能之间的关系仍未得到充分研究.
研究的目的:
- 在NAION患者中,研究周周皮囊胆道厚度 (PCT) 和胆道血管度指数 (CVI) 之间的关联.
- 探索PCT,CVI和NAION患者视觉功能之间的相关性.
主要方法:
- 扫描源光学连贯性断层扫描 (SS-OCT) 用于绘制NAION的17只眼睛,6只同眼睛和18只控制眼睛的图像.
- 测量了周周皮质冠状腺厚度 (PCT) 和冠状腺血管度指数 (CVI).
- 进行自动周边测量以评估视觉功能,并分析相关性.
主要成果:
- 与对照眼相比,受NAION影响的眼睛表现出明显更高的PCT和较低的CVI.
- 在受NAION影响的眼睛和同类眼睛之间没有发现PCT或CVI的显著差异.
- 视觉功能,特别是平均偏差,与非急性NAION眼中的鼻腔CVI正相关.
结论:
- NAION和未受影响的眼睛表现出增加的冠状腺厚度和减少的血管性.
- 周边表现与非急性影响的NAION眼睛的血管密度有关.
- 这些发现突出了胆道变化在NAION病原和病理生理学中的潜在作用.
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