索尔凝衍生B2O3-CaO酸生物活性眼镜具有静血,抗菌和益血管性活性
Kai Zheng1,2, Faina Bider3, Mahshid Monavari3
1Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, College of Stomatology, Nanjing Medical University, Nanjing 210029, China.
Regenerative biomaterials
|January 4, 2024
概括
生物活性玻璃提供可调节的离子释放,用于伤口愈合. 它们的成分影响着静血,抗菌和血管生成性质,使它们成为先进的伤口带的有前途产品.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 再生医学是一种再生医学.
背景情况:
- 索尔凝玻尿酸生物活性玻璃 (BGs) 是释放离子的生物材料.
- 这些材料显示出用于伤口愈合的潜在应用.
研究的目的:
- 为了合成和描述B2O3-CaO酸BGs.
- 研究CaO含量对BG特性和生物活性的影响.
- 评估它们适用于伤口愈合应用的适用性.
主要方法:
- B2O3-CaO酸BG的Sol-gel合成,其中的CaO含量各不相同 (50-90mol%).
- 对形态,结构和离子释放行为的分析.
- 在体外评估细胞毒性,静血,抗菌和血管新生活性.
主要成果:
- 增加的CaO含量减少了溶解和结晶,对形态的影响最小.
- 离子释放行为可以通过调整B2O3/CaO摩尔比来调整.
- 所有BG都细胞相容,具有组合依赖的静血,抗菌和血管新生活性.
- 较高的Ca含量增强了血液静止;较高的B含量促进了血管生成.
结论:
- 索尔凝衍生的酸BGs表现出可调节的离子释放和有利的生物活性.
- 这些BG是先进的伤口愈合带的有希望的候选人.
- 组合控制是优化BG性能用于伤口愈合的关键.
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