比亚甘利可尔通过COX-2/NF-κB信号通路抑制了TiPs刺激的骨质细胞形成和骨破坏
Zhidong Wang1, Huaqiang Tao1, Miao Chu1
1Department of Orthopedics, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215000, China.
Regenerative biomaterials
|January 4, 2024
概括
颗粒 (TiPs) 在人造关节周围引起炎症和骨质损失,导致无菌松动. 传统中医药Byakangelicol通过向炎症途径,有效抑制了TiP诱导的骨解.
科学领域:
- 生物材料科学 生物材料科学
- 免疫学 免疫学 免疫学
- 整形外科手术 整形外科手术
背景情况:
- 无菌松动 (AL) 是关节假肢失败的主要原因,通常是由磨损颗粒引起的炎症和骨质解脱引起的.
- 颗粒 (TiPs) 通过激活骨质细胞和促进慢性炎症,触发围围假骨解 (PPO).
研究的目的:
- 为了研究传统中医药化合物白甘醇的抗炎和抗骨解作用.
- 阐明byakangelicol减轻TiP诱导的PPO的机制.
主要方法:
- 在体外研究中评估了TiP对炎症基因表达 (COX-2,IL-1β,IL-6) 和骨质细胞激活的影响.
- 对TiP刺激的骨质细胞进行了评估,对Byakangelicol的疗效进行了评估,检查了它对巨分极和NF-κB信号传递的影响.
- 在骨解剖模型中的体内研究评估了byakangelicol的治疗潜力.
主要成果:
- TiPs显著提高了炎症基因的调节,并刺激了骨质细胞活性.
- 比亚甘利可尔通过抑制COX-2表达和调节巨细胞极化和NF-κB信号来抑制TiP诱导的骨质细胞激活.
- 在体内给予byakangelicol可降低炎症并减轻TiP诱导的骨解体.
结论:
- 比亚甘利可尔在预防和治疗周围假肢骨质溶解方面表现出显著的潜力.
- 用byakangelicol针对炎症途径提供了一个有前途的治疗策略,可以改善关节假肢的寿命并防止无菌松动.
相关概念视频
NF-κB-dependent Signaling Pathway
7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.4K
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
TGF - β Signaling Pathway
7.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.4K
The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Co-activators and Co-repressors
7.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.4K


