在减肥过程中大脑功能和肠道微生物组的动态变化
Jing Zhou1, Xiaoling Wu2, Tianyuan Xiang3
1Henan Provincial Research Center of Clinical Medicine of Nephropathy, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.
Frontiers in cellular and infection microbiology
|January 4, 2024
概括
间歇性能量限制 (IER) 在减肥期间改变了大脑活动和肠道微生物. 这项研究揭示了大脑-肠-微生物组轴的动态变化,影响了认知和感觉大脑区域.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢健康 代谢健康
背景情况:
- 间歇性能量限制 (IER) 是一种公认的减肥方法.
- 大脑-肠-微生物群 (BGM) 轴在代谢健康中起着至关重要的作用.
- 关于IER对BGM轴的动态影响的研究有限.
研究的目的:
- 研究IER对大脑活动的纵向影响.
- 分析IER诱导的体重减轻期间肠道微生物组成的变化.
- 探索大脑活动和肠道微生物群变化之间的相关性.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估大脑区域的活动.
- 便样本的元基因组测序以分析肠道微生物.
- 对25名接受为期2个月的IER干预的肥胖个体进行了纵向分析.
主要成果:
- IER 降低了与肥胖相关的大脑区域的活性,包括下额外轨道,门和前带状皮层.
- IER改变了肠道微生物群,减少了E. 大肠杆菌和增加的Faecalibacterium prausnitzii,Parabacteroides distasonis,和Bacterokles uniformis. 这两种细菌的分泌量都在不断增加.
- 在肠道细菌丰富度和大脑活动变化之间观察到显著的相关性.
结论:
- 在减肥过程中,IER会诱导大脑-肠-微生物群轴的动态变化.
- 特定的肠道微生物,如E. 大肠杆菌,显示与大脑区域的通信发生变化.
- 这些发现强调了饮食,肠道微生物群和大脑功能在体重管理中的相互联系.
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