在静脉静脉外体膜氧化6个月后,COVID后的肺功能变化:一项前性观察性临床试验
Alexandra Pálfi1, Ádám L Balogh1, Gabriella Polónyi1
1Department of Anesthesiology and Intensive Therapy, University of Szeged, Szeged, Hungary.
Frontiers in medicine
|January 4, 2024
概括
严重的COVID-19需要静脉静脉外体膜氧化 (V-V ECMO) 可以导致持续的小呼吸道功能障碍和放出后六个月的肺弹性降低. 这表明严重疾病导致的持续性呼吸系统损伤.
科学领域:
- 肺部病理学 肺部病理学
- 临界护理医学 临界护理医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 严重的COVID-19病例可能需要静脉静脉外体膜氧化 (V-V ECMO) 来治疗急性呼吸衰竭.
- 在严重的COVID-19期间需要V-V ECMO的患者的长期呼吸结果没有得到充分记录.
研究的目的:
- 综合评估接受V-V ECMO治疗严重COVID-19的患者的长期呼吸系统影响.
- 在这个患者队列中,在出院六个月后评估肺功能参数.
主要方法:
- 一项前性观察队列研究将9名接受V-V ECMO治疗的COVID-19患者与9名健康对照进行了比较.
- 呼吸系统振荡计 (测量R5,R19,AX5,R5-R19) 和螺旋计 (FEV1,FVC,FRC,DLCO,KCO) 在出院六个月后进行.
主要成果:
- COVID-19组的AX5和R5-R19水平较高,表明小气道功能受损和组织弹性降低.
- 与对照组相比,在COVID-19组中观察到较低的FEV1,FVC,FRC和DLCO.
- 对于COVID-19幸存者来说,KCO值保持在正常范围内.
结论:
- 严重的COVID-19需要V-V ECMO导致小气道功能持续受损,呼吸道组织弹性降低.
- 这些发现表明,在急性COVID-19后的6个月内,可能是由于肺部的限制而导致的中度,持久的肺功能缺陷.
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