在SARS-CoV-2阳性和阴性个体中普遍存在的长期COVID相关症状:一项潜在的后续研究
Anu Kantele1,2,3, Juuso Paajanen4, Jukka-Pekka Pietilä1,3
1Meilahti Infectious Diseases and Vaccine Research Center, MeiVac, Biomedicum 1, Haartmaninkatu 8, Helsinki University Hospital and University of Helsinki, 00290, Helsinki, Finland.
New microbes and new infections
|January 4, 2024
概括
长期COVID症状在住院COVID-19患者中比在门诊患者中更常见. 然而,许多症状在负控制组中也很常见,这表明门诊患者的长期COVID流行率很低.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在SARS-CoV-2感染 (长期COVID) 后的持续症状主要研究在住院患者中.
- 这项研究调查了SARS-CoV-2阳性 (CoV(+)) 和阴性 (CoV(-)) 个体的长期COVID症状.
研究的目的:
- 为了比较实验室确认的SARS-CoV-2阳性和阴性个体之间的长期COVID相关症状的流行率和类型.
- 为了区分长期COVID特有的症状与一般人群所经历的症状.
主要方法:
- 展望后续研究涉及四个队列:Cov(+) 门诊患者,Cov(-) 门诊患者,Cov(+) 重症监护室 (ICU) 住院患者和Cov(+) 非ICU住院患者.
- 评估中和抗体和多个时间点在注册后533天内进行的症状问卷.
主要成果:
- 在1326名参与者中,1191名是Cov(+) 和135名是Cov(-) 对照.
- CoV(+) 门诊患者和 CoV(-) 对照报告了高症状率;只有 CoV(+) 门诊患者的嗅觉和味觉受损更为频繁.
- 长期COVID症状,如疲劳和呼吸障碍,在COV(+) 住院患者中比门诊患者在181天后更为常见.
结论:
- 在住院的SARS-CoV-2患者中,长期COVID症状的频率明显高于非住院患者.
- 对于门诊患者来说,只有嗅觉和味觉障碍在Cov(+) 组中更高,在Cov(-) 个体中,一些症状更常见.
- 这项研究强调了负控制对准确评估长期COVID流行病的重要性,特别是在门诊患者中.
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