使用常规参数对移植接受者的风险分层:从SARS-CoV-2中学习到移植后续计划中的意义
Abbas Ghazanfar1, Madiha Abbas2, Md Walid Hussain3
1Renal and Transplant Unit, St Georges University Hospitals NHS Foundation Trust, London SW17 0QT, United Kingdom. a.ghazanfar@nhs.net.
World journal of transplantation
|January 4, 2024
概括
这项研究确定了关键的人口和实验室标记,以预测COVID-19移植患者的死亡风险. 早期识别年龄,种族和低白蛋白等因素可以改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植手术 移植手术
- 传染性疾病 传染性疾病
背景情况:
- 严重急性呼吸道综合征冠状病毒-2 (SARS-CoV-2) 对实体器官移植接受者构成重大死亡风险.
- 鉴定SARS-CoV-2移植受体 (RTxR) 死亡率的预测因素对于管理大流行影响至关重要.
研究的目的:
- 以风险分层RTxR基于人口统计学,并发症和常规实验室标记物来确定疾病严重程度和结果.
- 通过使用常规监测的参数,为RTxR的后续计划策略提供信息.
主要方法:
- 在2020年3月至2021年2月期间感染SARS-CoV-2的RTxR的回顾性分析.
- 收集人口统计数据,并发症和常规实验室标记.
- 调查SARS-CoV-2对RTxR的影响,包括疾病进展,恢复和死亡风险分层.
主要成果:
- 在505个RTxR中,有29个 (7.75%) 患有SARS-CoV-2;有8例死亡 (感染者死亡率为27.6%).
- 与死亡率增加相关的因素包括年龄>68岁,非高加索族裔,男性性别,糖尿病,低EGFR (<26),低血清白蛋白 (<20),低血红蛋白 (<9.6) 和低血清 (<1.70).
结论:
- 常规监测的人口和实验室参数可以预测RTxR后SARS-CoV-2感染的较高死亡率和发病率风险.
- 在RTxR后续计划中利用这些参数可以帮助减轻不良结果.
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