设计和应用的histidine功能化的ZnCr-LDH纳米酶促进细菌感染的伤口愈合
Sonya Dadakhani1, Gholamreza Dehghan1, Alireza Khataee2,3
1Department of Biology, Faculty of Natural Sciences, University of Tabriz 51666-16471 Tabriz Iran gdehghan@tabrizu.ac.ir.
RSC advances
|January 4, 2024
概括
新的纳米酶结合了histidine和-层双氧化物 (His/ZnCr-LDH) 显示出强大的抗菌活性. 这种用酸增强的方法有效地消除细菌,促进伤口愈合,为抗生素提供了一个有希望的替代品.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 纳米技术纳米技术
背景情况:
- 抗生素耐药性是一个日益增长的全球健康威胁.
- 纳米酶提供了一个有前途的替代品,因为它们的活性氧物种 (ROS) 产生抗菌性质.
- 开发具有增强疗效的新型纳米酶至关重要.
研究的目的:
- 为了合成和表征胺修饰的ZnCr层状双氧化物 (His/ZnCr-LDH) 纳米酶.
- 通过ROS生成研究His/ZnCr-LDH的酸增强抗菌活性.
- 在受感染的伤口模型中评估His/ZnCr-LDH的治疗潜力.
主要方法:
- 由自然酶启发的His/ZnCr-LDH的合成.
- 对类似酶的活性进行色度评估.
- 使用葡萄糖氧化酶和葡萄糖开发一种以酸增强的抗菌策略.
- 对*S. aureus*和*E. coli*的最低抑制度 (MIC) 的确定.
- 在体内进行动物实验,以评估伤口愈合.
主要成果:
- 他的/ZnCr-LDH表现出显著的过氧化酶类活性.
- 增强酸的策略有效地促进了ROS生成.
- 达到的低MIC值:S. aureus的3.5微克每升-1,E. coli的6微克每升-1.
- 在动物模型中证明成功加速受感染的伤口愈合.
结论:
- 氨基酸改性层状双氧化物为对抗细菌感染提供了一种新的策略.
- 他的/ZnCr-LDH显示出有效消除细菌和治疗伤口的巨大潜力.
- 这种方法为开发用于各种医疗应用的新抗菌剂提供了有希望的途径.
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