细胞损失启动微血管功能障碍在扩张性功能障碍的发展
Steven J Simmonds1, Mandy O J Grootaert1, Ilona Cuijpers1,2
1Centre for Molecular and Vascular Biology, KU Leuven, Herestraat 49, bus 911, Leuven 3000, Belgium.
European heart journal open
|January 4, 2024
概括
细胞损失是心力衰竭中微血管功能障碍的早期驱动因素,具有保存的喷射分数 (HFpEF). 这种围细胞功能障碍促进了内皮炎症,加速了HFpEF的发育.
科学领域:
- 心血管生物学 心血管生物学
- 血管细胞生物学 血管细胞生物学
- 心脏衰竭病理生理学 病理生理学
背景情况:
- 微血管功能障碍与心力衰竭有关,心力衰竭具有保存的喷射分数 (HFpEF).
- 最初的分子和细胞事件驱动HFpEF相关的微血管变化仍然不清楚.
- 了解这些早期事件对于开发有效的HFpEF疗法至关重要.
研究的目的:
- 调查HFpEF中微血管变化的时间发作.
- 阐明皮质细胞功能障碍在HFpEF进展中的作用.
- 为了确定皮质细胞功能障碍如何导致心脏功能障碍.
主要方法:
- 在6周,14周和21周使用了HFpEF的Zucker脂肪和自发高血压 (ZSF1) 肥胖大鼠模型.
- 评估了微血管功能障碍,包括炎症激活和内皮屏障功能.
- 研究了一种小鼠模型,其皮质细胞覆盖率降低 (PDGF-B) 和在氧化应激下体外皮质细胞模型.
主要成果:
- 细胞损失是最早的微血管变化,先于腹功能障碍.
- 肥胖的ZSF1大鼠在14周后表现出衰细胞增殖的减少,形态的改变和毛细血管直径的增加.
- 在小鼠中,皮质细胞覆盖率的减少导致了腹结功能障碍;在体外,氧化应激会损害皮质细胞并诱导内皮质炎症.
结论:
- 细胞对于维持内皮细胞功能和微血管完整性至关重要.
- 皮质细胞的损失会加剧内皮质炎症反应.
- 细胞功能障碍促进了微血管功能障碍,加速了HFpEF的发展.
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