吸入氧化对在急性缺氧运动期间最大氧气消耗的影响:一项随机双盲交叉试验
Zahrah H Rampuri1,2, Sophie É Collins1,2, Benjamin S A Mickelsen1,3
1Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
吸入氧化 (iNO) 在中度和重度缺氧期间没有改善最大氧气消耗 (V·o2max) 或心脏输出峰值. 这项研究研究了iNO.
科学领域:
- 运动生理学 运动生理学
- 心血管生理学心血管生理学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 低氧降低了最大的氧气消耗 (V·o2max) 在中度条件下通过动脉脱和在严重条件下通过升高的肺动脉压力 (PAP).
- 在严重的缺氧中,PAP升高可能会损害心脏输出峰值,从而限制V·o2max.
研究的目的:
- 为了调查吸入的氧化 (iNO),一个肺血管扩展剂,是否可以增加V·o2max在中度和严重的急性缺氧.
- 为了确定iNO对肺动脉压力 (PAP) 和低氧条件下的运动能力的影响.
主要方法:
- 一项随机,双盲,交叉研究,涉及12名健康参与者.
- 心肺运动测试 (CPET) 在急性中度 (89 mmHg) 和严重 (79 mmHg) 缺氧的情况下进行,有或没有40 ppm iNO.
- 在所有条件下使用心声成像来测量静止右心室缩压 (RVSP/PAP).
主要成果:
- 在中度缺氧 (P = 0.01) 时,iNO显著减少了2.5 mmHg的静止RVSP,在严重缺氧 (P = 0.05) 时降低了1.8 mmHg.
- 尽管PAP减少了,但iNO在任何低氧状态下都没有影响心脏输出峰值或V·o2max.
- 这些发现表明,用iNO减少PAP在急性缺氧期间不会提高健康个体的运动耐受性.
结论:
- 吸入的氧化有效地降低了急性中度和严重缺氧的肺动脉压力.
- 然而,在这些低氧条件下,iNO不会改善健康个体的峰值心脏输出或最大氧气消耗.
- 结果表明,在急性缺氧暴露期间,增加的PAP可能不是健康个体对运动耐受性的主要限制因素.
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