改变了慢性肺炎患者的呼吸的运动肌肉代谢反射控制
Liliane C Aranda1,2, Indyanara C Ribeiro1,2, Tiago O Freitas1,2
1Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Medicine, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Journal of applied physiology (Bethesda, Md. : 1985)
|January 4, 2024
概括
慢性阻塞性肺病 (COPD) 改变了肌肉代谢反射的呼吸控制,增加了通风,但没有喘息. 慢性肺炎患者的分子变化表明改变的肌肉信号有助于这种效果.
科学领域:
- 整合生理学 整合生理学
- 呼吸系统药物 呼吸系统药物
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 运动肌肉的代谢反射影响通风和血液循环.
- 慢性阻塞性肺病 (COPD) 的特点是呼吸和全身影响.
- 了解COPD的反射控制变化对于管理疾病至关重要.
研究的目的:
- 为了研究COPD对运动肌肉代谢反射控制通风,血液循环和呼吸障碍的影响.
- 探索骨肌肉中潜在的分子机制.
主要方法:
- 10名COPD患者和9名对照人进行了循环运动,并进行了运动后的循环阻塞,以激活代谢反射.
- 用冷压器测试来评估反射特异性.
- 骨肌肉活检分析了纤维类型,谷氨氧化还原平衡和神经生长因子 (NGF) mRNA.
主要成果:
- 代谢反射激活增加了COPD患者的通风,但不是对照组.
- 呼吸障碍在代谢反射激活期间在对照人群中增加,但不是在COPD患者中.
- 与对照组相比,COPD患者表现出较高的II型肌细胞百分比,较低的谷氨比率和减少的NGF mRNA表达.
结论:
- 慢性肺炎会改变运动肌肉代谢反射对通风的控制,增加通风,而不会导致呼吸障碍的相应增加.
- 增加的II型肌细胞和氧化还原失衡可能会增强COPD中的代谢受体刺激.
- 降低NGF的调节表明,COPD患者的肌肉 afferent信号发生变化.
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