相关实验视频
Updated: Jul 6, 2025

09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
15.9K
用于输送抗真菌药物的纳米治疗药物
1Department of Chemistry University of Fort Hare, Alice Eastern Cape, 5700, South Africa.
Therapeutic delivery
|January 4, 2024
概括
基于聚合物的纳米疗法通过改善抗真菌药物输送,为真菌感染提供了有希望的解决方案. 这种方法提高了药物的有效性,并克服了当前治疗方法的局限性,特别是对于免疫功能低下的患者.
科学领域:
- 制药科学 制药科学
- 生物技术是生物技术.
- 传染性疾病 传染性疾病
背景情况:
- 由于高死亡率,真菌感染带来了重大挑战,特别是对于免疫力低下的人来说.
- 目前的抗真菌药物表现出局限性,包括生物可用性,溶解性,药理动力学和耐药性差,以及受限的细胞吸收.
- 在临床开发中新型抗真菌剂的稀缺性需要创新的治疗策略.
研究的目的:
- 审查和总结各种基于聚合物的纳米载体策略,用于抗真菌药物输送.
- 突出纳米疗法在提高现有抗真菌剂的疗效方面的潜力.
- 讨论纳米载体系统如何解决传统抗真菌治疗的局限性.
主要方法:
- 关于研究聚合物基纳米载体用于抗真菌药物输送的研究的文献综述.
- 对不同纳米载体配方及其对药物特性影响的分析.
- 对纳米治疗抗真菌剂报告的治疗结果的评估.
主要成果:
- 基于聚合物的纳米疗法证明了改善的药理动力学和药物循环时间.
- 这些系统有助于针对性和持续地向感染部位提供抗真菌药物.
- 纳米疗法已经显示出克服现有的耐药性机制和增强细胞吸收的潜力.
结论:
- 基于聚合物的纳米疗法是改善真菌感染治疗的可行策略.
- 这种方法比免费的抗真菌药物具有显著的优势,包括改善治疗结果和克服耐药性.
- 进一步开发抗真菌纳米治疗药物有望解决治疗侵袭性真菌病的未满足医疗需求.
相关概念视频
Drug Delivery: Miscellaneous Routes
345
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
345
Drug Delivery: Overview
294
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
294
Drug Delivery: Enteral Route
456
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
456
Factors Affecting Dissolution: Particle Size and Effective Surface Area
851
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
851
Drug Delivery: Parenteral Route
539
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
539
Additional Routes of Drug Administration
2.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.8K

