一个患有中风后的病人中的肉毒神经毒素-A:神经生理学研究
Safa Muntadher Fawzi1, Farqad Bader Hamdan1, Israa F Jaafar2
1Department of Physiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
Folia neuropathologica
|January 4, 2024
概括
肉毒神经毒素-A (BoNT-A) 有效地治疗中风后性 (PSS),改善肌肉功能和减少性. 这种治疗也对神经生理学指标产生积极影响,例如H反射,这表明运动神经元刺激性降低.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 临床神经学 临床神经学
背景情况:
- 脑卒中后性 (PSS) 是一种常见的运动障碍,由上部运动神经元病变引起.
- 玻尿酸神经毒素-A (BoNT-A) 是在康复环境中用于焦点PSS的公认治疗方法.
- 了解BoNT-A对PSS中运动神经元刺激性的神经生理影响至关重要.
研究的目的:
- 评估BoNT-A对PSS患者上肢和下肢H反射的影响.
- 调查性严重程度 (修改的阿什沃思尺度) 和运动神经元池刺激性 (H-反射) 之间的相关性.
主要方法:
- 50名患有焦点上肢或下肢PSS的患者 (30-60岁) 接受了两次BoNT-A注射.
- 在治疗前和治疗后,测量H反射从柔软的carpi radialis和肌底肌肉.
- 用修改的阿什沃思尺度 (MAS) 和医学研究委员会 (MRC) 尺度评估了性和肌肉强度.
主要成果:
- 在BoNT-A治疗后观察到H-反射延迟,幅度和H/M比率的显著变化.
- 在MRC尺度显著增加,表明肌肉强度有所改善.
- MAS显著下降,表明性减少.
结论:
- 服用BoNT-A导致PSS显著的临床改善,由减少性 (MAS) 和增加肌肉强度 (MRC) 证明.
- 通过H-反射的神经生理学评估证实BoNT-A在调节运动神经元刺激性的有效性.
- 在H-反射延迟和MAS之间发现了负相关性,这表明运动神经元刺激性降低与性降低有关.
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